Changes are at a minimum for Saturday's Calcutta Cup match with Scotland unchanged from the side that beat Scotland in round two, and England making just one tweak to their starting lineup.
Nathan Hughes returns to replace the injured Sam Simmonds at No 8 while prop Joe Marler is a replacement after completing his suspension.
Joe Launchbury (Wasps) will play in his 50th game for England having made his debut for his country in 2012.
Meanwhile, Captain Dylan Hartley will become England’s second most capped men's player of all time when he steps out for the 92nd time on Saturday. Hartley will surpass Jonny Wilkinson on 91 caps and now only sits behind Jason Leonard (114).
When? Saturday, 24 February
Where? Murrayfield Stadium
Follow the action
- Live on BBC Sport from 4pm.
- Live commentary on BBC Radio 5 live
- Live text commentary on EnglandRugby.com
- Live score updates from @EnglandRugby on Twitter
- Match report, post-match highlights and interviews on EnglandRugby.com
Keys to the game
As England prepare to travel to Murrayfield to take on a Scotland, former England scrum half Matt Dawson says the whole squad must be prepared for the atmosphere that awaits.
Dawson also looks at line breaks, turnovers and set piece ball as he analyses the 'Key Targets' ahead of Saturday's Calcutta Cup match.
Views from the camp
England head coach Eddie Jones:
“It is a massive game the Calcutta Cup, you don’t get any bigger than this.
“I can remember as a kid watching all the great Scotland sides: Gavin Hastings at full back, Finlay Calder, John Jeffries and Colin Deans. They had great teams that played with a lot of passion and a lot of conviction and that is what Gregor is trying to get with his team, so this is a big occasion.
“We are really focussed intensely on this game, we’ve had a well-coordinated, cohesive preparation and we are ready to go. Scotland are a good side, we respect them, and we have to be at our best to beat them.”
England hooker Jamie George: "I think we're pretty aware of the gameplan that they want to try and put on us and bring to us.
"In terms of the way that Gregor Townsend coaches them I think they're a very well drilled team that look to throw the ball around a lot, but at the same time stress the importance of their set piece.
"I think their set piece has come under quite a lot of scrutiny before the tournament and I think they've proven quite a few people wrong in the first few games, they've got a very well drilled set piece.
"They are a very different team to the one we played last year and I think it's going to be a seriously exciting contest come Saturday."
- February 2017: England 61 Scotland 21, Twickenham
- February 2016: Scotland 9 England 15, Murrayfield
- March 2015: England 25 Scotland 13, Murrayfield
- February 2014: Scotland 0 England 20, Murrayfield
- February 2013: England 38 Scotland 18, Twickenham
- February 2012: Scotland 6 England 13, Murrayfield
- March 2011: England 22 Scotland 16, Twickenham
Key stats and facts
- England have won 24 of their 25 games under Eddie Jones, losing only in Ireland.
- They are on a run of seven straight victories since that defeat, while their only two losses in the last 21 Six Nations fixtures both came in Dublin.
- Since 2000, Scotland have scored just two tries in nine home games versus England, and none since 2004.
- England have won their last three games at Murrayfield - their best run in the Six Nations.
15 Mike Brown (Harlequins 66 caps), 14 Anthony Watson (Bath Rugby 30 caps), 13 Jonathan Joseph (Bath Rugby 37 caps), 12 Owen Farrell (Saracens 55 caps), 11 Jonny May (Leicester Tigers 31 caps), 10 George Ford (Leicester Tigers 42 caps), 9 Danny Care (Harlequins 78 caps), 1 Mako Vunipola (Saracens 46 caps), 2 Dylan Hartley (Northampton Saints 91 caps), 3 Dan Cole (Leicester Tigers 79 caps), 4 Joe Launchbury (Wasps 49 caps), 5 Maro Itoje (Saracens 16 caps), 6 Courtney Lawes (Northampton Saints 63 caps), 7 Chris Robshaw (Harlequins 61 caps), 8 Nathan Hughes (Wasps 12 caps).
16 Jamie George (Saracens 22 caps), 17 Joe Marler (Harlequins 53 caps), 18 Harry Williams (Exeter Chiefs 7 caps), 19 George Kruis (Saracens 23 caps), 20 Sam Underhill (Bath Rugby 5 caps), 21 Richard Wigglesworth (Saracens 28 caps), 22 Ben Te’o (Worcester Warriors 10 caps), 23 Jack Nowell (Exeter Chiefs 25 caps).
Scotland: Hogg, Seymour, Jones, Horne, Maitland, Russell, Laidlaw; Reid, McInally, Berghan, Gilchrist, J Gray, Barclay (capt), Watson, Wilson.
Replacements: Lawson, J Bhatti, WP Nel, Swinson, Denton, Price, Grigg, Kinghorn.
Referee: Nigel Owens (Wales)
Touch judges: Jerome Garces (France) & Andrew Brace (Ireland)
TMO: Simon McDowell (Ireland)