Following medical assessments Mako Vunipola (Saracens) has been ruled out of England’s Guinness Six Nations campaign with an ankle ligament injury.
Vunipola picked up the injury during England’s win against France on Sunday and is expected to be out for 10 weeks.
The England prop will begin his rehabilitation with his club Saracens.
“It is obviously very disappointing to lose Mako at this stage as he is an important player for us but it does provide an opportunity for the team to grow," said England head coach Eddie Jones.
England will assemble in central London tomorrow (Wednesday) lunchtime for a three-day camp ahead of their next match against Wales on the 23 February in Cardiff.